A DRUG WITH A HALF-LIFE OF 12 HOURS IS ADMINISTERED BY CONTINUOUS INTRAVENOUS INFUSION. HOW LONG WILL IT TAKE FOR THE DRUG TO REACH 90% OF ITS FINAL STEADY STATE LEVEL?

1. A drug with a half-life of 12 hours is administered by continuous intravenous infusion. How long will it take for the drug to reach 90% of its final steady state level?

2. In what manner could one double the steady-state concentration of a drug?

3. Evaluate the follow statements. Do you agree or disagree? Explain your answer. a. If 10 mg of drug A produces the same response as 100 mg of drug B, drug A is more efficacious than drug B b. The greater the efficacy, the greater the potency of a drug c. In selecting a drug, potency is usually more important the efficacy d. A competitive antagonist increases ED50 e. Variation in response to a drug among different individuals is most likely to occur with a drug showing a large therapeutic index

4. What is the estimated clearance rate of a drug which is infused at a rate of 4 mg/min and produces a steady-state concentration of 6 mg/L?

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